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KMID : 1134820090380081008
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Journal of the Korean Society of Food Science and Nutrition
2009 Volume.38 No. 8 p.1008 ~ p.1015
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Effect of Rosmarinus officinalis L. on Growth Inhibition and Apoptosis Induction in Cancer Cells
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Choi Jun-Hyeok
Lee In-Seon
Kim Hyuk-Ii
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Abstract
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The goal of this study was to evaluate the anticancer effect of Rosmarinus officinalis L. In this study induction of apoptosis by methanol extract of rosemary and their fractions were investigated in vitro. In examining the effect of rosemary methanol extract on the inhibition of growth of Hela, HepG2, A549, AGS cells and HT-29 cell, it was found that the methanol extract of rosemary and their fractions demonstrated a cytotoxic effect in a dose-dependent manner; in addition, hexane and chloroform fractions showed a particularly high cytotoxic effect on Hela and AGS cells. The results showed that the hexane and chloroform fractions of rosemary have cytotoxic effect which are related to the activity of the essential oil in the rosemary. Apoptosis in Hela and AGS cells mediated by the hexane and chloroform fractions was associated with the increase of cleaved caspase-3 levels and cleaved PARP. Therefore, with more researches on identification and action mechanism of active compound, the hexane and chloroform fractions are expected to be natural sources for the developments of functional food and medical agents to prevent gastric cancer and uterus cancer.
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KEYWORD
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Rosmarinus officinalis L., apoptosis, Hela cells
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